PFCL (Perfluorodecaline) Assortment
Perfluorocarbons are colorless, non-toxic, chemically and physiologically inert and are widely used in vitreoretinal surgery for the relaxation of the retina. The surface tension and the contact are such as to avoid the risk of migration of these compounds under the retina in the case of giant tears. Due to their high density, that for PFCL (Perfluorodecaline) has a typical value of 1,941 g/ml, the perfluorocarbon liquids are considered excellent products to relax and also re-adhere the detached retina (while the silicone oil is the product of choice for the next buffering).
However, perfluorocarbons have also such characteristics that they are not recommended for long-term use.
Despite perfluorocarbons are absolutely non-toxic, the use of this compounds is only permitted during intraoperative phases, they must always be removed at the end of the surgical procedure because their stay in the eye causes retinal changes within a relatively short time.
Perfluorocarbons can not be mixed with silicone oil. For this reason, in case of buffering with silicone oil subsequent to the use of PFCL, the residual drops eventually not removed, will dissolve very slowly and, if a significant quantity, may give rise to emulsions.
PFCL must be inserted into the vitreous cavity only after having removed with care the central vitreous and in
most complicated cases the peripheral vitreous. Anyhow before infusion must check that there is no free vitreous or vitreous that could mix with the PFCL itself. If the eye is sealed make sure there is a way to vent while injecting the substance in order to avoid a dangerous ocular hypertension. You should still check the papilla, during infusion, to make sure of proper blood supply to the vessels.
Immediately after the washing and removing the liquid and solid residues, remove the substance from the eye within one hour.